Tier 1 — highest

Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial

Axel C P Diederichsen, Jes S Lindholt, Sören Möller, Kristian A Øvrehus, Søren Auscher, Jess Lambrechtsen, Susanne E Hosbond, Dilek H Alan, Grazina Urbonaviciene, Søren W Becker, Maise H Fredgart, Selma Hasific, Lars Folkestad, Oke Gerke, Lars Melholt Rasmussen, Jacob E Møller, Hans Mickley, Jordi S Dahl
Circulation 2022 145(18):1387-1397

Bibliography

PubMed
PMID 35465686
PubMed Central
PMC9047644
DOI
10.1161/CIRCULATIONAHA.121.057008
Trial registry
View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample365 men with substantial aortic valve calcification randomized
Intervention720 μg/day MK-7 plus 25 μg/day vitamin D, versus placebo
Duration24 months
EndpointsAortic valve calcification progression; Valve function; Coronary and aortic calcification; dp-ucMGP

What the study showed, in plain terms

This publication examines aortic valve calcification progression, valve function, coronary and aortic calcification, dp-ucmgp. Study population or evidence base: 365 men with substantial aortic valve calcification randomized. Intervention or exposure: 720 μg/day MK-7 plus 25 μg/day vitamin D, versus placebo.

Key findings

MK-7 plus vitamin D lowered the vitamin K-status biomarker dp-ucMGP but did not significantly slow aortic valve calcification or improve valve-function measures.

What this study can and cannot tell us

The trial concerns older men with established calcification, using a higher MK-7 dose than many retail products. Subsequent coronary analyses belong to this same AVADEC trial.

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