Tier 1 — highest

Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial

Qi Dai, Xiangzhu Zhu, JoAnn E Manson, Yiqing Song, Xingnan Li, Adrian A Franke, Rebecca B Costello, Andrea Rosanoff, Hui Nian, Lei Fan, Harvey Murff, Reid M Ness, Douglas L Seidner, Chang Yu, Martha J Shrubsole
The American journal of clinical nutrition 2018 108(6):1249-1258

Bibliography

PubMed
PMID 30541089
PubMed Central
PMC6693398
DOI
10.1093/ajcn/nqy274
Trial registry
View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
Funding
Support is recorded from NIDDK NIH HHS, NCI NIH HHS, NCRR NIH HHS, NCATS NIH HHS. See the original publication for grant and material-support details.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample180 adults aged 40–85 in an ancillary analysis of the PPCCT trial
InterventionPersonalized oral magnesium or placebo, adjusted to baseline dietary intake
Duration12 weeks
EndpointsCirculating vitamin D metabolites; Interaction with baseline 25(OH)D

What the study showed, in plain terms

This publication examines circulating vitamin d metabolites, interaction with baseline 25(oh)d. Study population or evidence base: 180 adults aged 40–85 in an ancillary analysis of the PPCCT trial. Intervention or exposure: Personalized oral magnesium or placebo, adjusted to baseline dietary intake.

Key findings

Magnesium altered vitamin D metabolism in a way that depended on starting vitamin D status. It increased 25(OH)D3 near a baseline of 30 ng/mL but lowered it at higher baseline levels.

What this study can and cannot tell us

This ancillary biomarker study did not test a fixed D3/K2/magnesium capsule or establish disease prevention. The response was not a uniform increase in vitamin D.

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