Tier 1 — highest

Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone Strength: A Randomized Clinical Trial

Lauren A Burt, Emma O Billington, Marianne S Rose, Duncan A Raymond, David A Hanley, Steven K Boyd
JAMA 2019 322(8):736-745

Bibliography

PubMed
PMID 31454046
PubMed Central
PMC6714464
DOI
10.1001/jama.2019.11889
Trial registry
View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
Funding
Support is recorded from Pure North S’Energy Foundation. See the original publication for grant and material-support details.
Competing interests
The publication includes author disclosures; consult the linked source for the individual relationships and their relevance.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample311 healthy adults aged 55–70 in the bone-imaging analysis
InterventionVitamin D3 400, 4,000 or 10,000 IU/day; calcium added when indicated
Duration3 years
EndpointsRadius and tibia volumetric bone density; Estimated bone strength

What the study showed, in plain terms

This publication examines radius and tibia volumetric bone density, estimated bone strength. Study population or evidence base: 311 healthy adults aged 55–70 in the bone-imaging analysis. Intervention or exposure: Vitamin D3 400, 4,000 or 10,000 IU/day; calcium added when indicated.

Key findings

Higher doses did not improve estimated bone strength. Radial volumetric density declined more with 4,000 and 10,000 IU/day than with 400 IU/day.

What this study can and cannot tell us

Participants did not have osteoporosis and were not markedly deficient. The findings concern measured bone structure rather than an established increase in fractures.

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