Tier 4 — mechanistic

Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium

Vishnudutt Purohit, Manal F Abdelmalek, Shirish Barve, Norlin J Benevenga, Charles H Halsted, Neil Kaplowitz, Kusum K Kharbanda, Qi-Ying Liu, Shelly C Lu, Craig J McClain, Christine Swanson, Samir Zakhari
The American journal of clinical nutrition 2007 86(1):14-24

Bibliography

PubMed
PMID 17616758
DOI
10.1093/ajcn/86.1.14
Funding
Indexed grant support: P30 DK048522 — NIDDK NIH HHS — United States; P50 AA11999 — NIAAA NIH HHS — United States; R01 AA010496 — NIAAA NIH HHS — United States; R01 AA012677 — NIAAA NIH HHS — United States; R01 AA013847 — NIAAA NIH HHS — United States; R01 AA014145 — NIAAA NIH HHS — United States; R01 AA014371 — NIAAA NIH HHS — United States; R01 AA014428 — NIAAA NIH HHS — United States; R01 AA015970 — NIAAA NIH HHS — United States; R01 AT01576 — NCCIH NIH HHS — United States; R01 DK051719 — NIDDK NIH HHS — United States; R01 DK071765 — NIDDK NIH HHS — United States; R37 AA010762 — NIAAA NIH HHS — United States. The indexed list may not contain the complete funding declaration.
Competing interests
A competing-interest declaration was not available in the indexed record or accessible disclosure metadata.

Study snapshot

DesignNarrative review
ModelEvidence synthesis; mixed research models
SamplePublished literature; no newly enrolled participant cohort
InterventionReview of betaine-related evidence; no single assigned intervention
DurationEvidence review; source-specific study durations vary
EndpointsBetaine biology; Clinical and mechanistic evidence

What the study showed, in plain terms

Published in 2007, this source examined mechanistic and clinical reviews. Its evidence base was Published literature; no newly enrolled participant cohort. It evaluated Review of betaine-related evidence; no single assigned intervention across Evidence review; source-specific study durations vary.

Summarizes a symposium on SAMe, folate and betaine mechanisms in alcohol-associated liver injury.

A mechanistic symposium report with multiple nutrients; it is not a new randomized clinical trial.

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Key findings

  • Summarizes a symposium on SAMe, folate and betaine mechanisms in alcohol-associated liver injury.
  • The recorded outcome domains were Betaine biology; Clinical and mechanistic evidence.

What this study can and cannot tell us

  • A mechanistic symposium report with multiple nutrients; it is not a new randomized clinical trial.
  • The conclusions inherit the limitations of the underlying studies. A narrative interpretation or guideline recommendation is not a new randomized treatment comparison.
  • Source basis: Indexed abstract and bibliographic data. Missing method details, funding information or participant denominators are not inferred.

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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology