Tier 2 — strong
Berberine and Adiposity in Diabetes-Free Individuals With Obesity and MASLD: A Randomized Clinical Trial
JAMA network open
2026
9(1):e2554152
Bibliography
- PubMed
- PMID 41543854
- PubMed Central
- PMC12811813
- Trial registry
- View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
- Funding
- Supported by the China Academy of Chinese Medical Sciences Innovation Fund; study drugs were supplied free by Yunnan Biovalley Pharmaceutical.
- Competing interests
- The authors reported no conflicts of interest. Free study-drug supply is disclosed in the funding statement.
Study snapshot
| Design | Multicenter double-blind placebo-controlled randomized trial |
|---|---|
| Model | Human participants; see population |
| Sample | 337 randomized; 169 berberine and 168 placebo |
| Intervention | Berberine hydrochloride 500 mg twice/day versus placebo; lifestyle advice in both arms |
| Duration | 6 months |
| Endpoints | Liver fat and liver enzymes; Body composition and weight; Metabolic biomarkers |
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