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The Effect of Berberine on Lipid Profile, Liver Enzymes, and Fasting Blood Glucose in Patients with Non-alcoholic Fatty Liver Disease (NAFLD): A Randomized Controlled Trial

Nejati L, Movahedi A, Salari G, Moeineddin R, Nejati P
Medical journal of the Islamic Republic of Iran 2022 36:39

Bibliography

PubMed
PMID 36128280
PubMed Central
PMC9448505
Funding
Funding was not established from the accessible source; this is not a declaration of no funding.
Competing interests
The authors declared no competing interests in the publication.

Study snapshot

DesignRandomized lifestyle-controlled study with nonstandardized boiled preparation
ModelHuman participants; see population
Sample50 adults; 25 per arm
InterventionBoiled preparation described as 6.25 g/day dried material; active alkaloid content not standardized
Duration45 days; described inconsistently as 6–7 weeks
EndpointsLiver fat and liver enzymes; Body composition and weight; Metabolic biomarkers

What the study showed, in plain terms

This small fatty-liver trial did not detect significant between-group improvements in glucose, lipids, liver enzymes or weight. The preparation was made by boiling dried material and cannot be treated as 6.25 g of isolated berberine.

Key findings

  • This small fatty-liver trial did not detect significant between-group improvements in glucose, lipids, liver enzymes or weight. The preparation was made by boiling dried material and cannot be treated as 6.25 g of isolated berberine.

What this study can and cannot tell us

Unclear botanical/alkaloid specification and inconsistent masking terminology substantially limit interpretation.

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