Tier 2 — strong

Does berberine impact anthropometric, hepatic, and metabolic parameters in patients with metabolic dysfunction-associated fatty liver disease? Randomized, double-blind placebo-controlled trial

Koperska A, Moszak M, Seraszek-Jaros A, Bogdanski P, Szulinska M
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2024 75(3)

Bibliography

PubMed
PMID 39042390
DOI
10.26402/jpp.2024.3.06
Funding
Funding was not established from the accessible source; this is not a declaration of no funding.
Competing interests
A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Study snapshot

DesignRandomized double-blind placebo-controlled trial
ModelHuman participants; see population
Sample70 adults with MAFLD
InterventionBerberine 1500 mg/day versus placebo
Duration12 weeks
EndpointsLiver fat and liver enzymes; Body composition and weight; Metabolic biomarkers

What the study showed, in plain terms

The study found selected liver-enzyme and total-cholesterol improvements, while most other glucose and lipid outcomes were not significantly different between arms.

Key findings

  • The study found selected liver-enzyme and total-cholesterol improvements, while most other glucose and lipid outcomes were not significantly different between arms.

What this study can and cannot tell us

Multiple surrogate endpoints and brief observation; within-group loss of trunk fat in both arms does not establish a berberine effect.

Source detail: indexed abstract and bibliographic record; unavailable methods or disclosures are identified rather than assumed.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology