Tier 2 — strong
Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)
Nature communications
2020
11(1):5015
Bibliography
- PubMed
- PMID 33024120
- PubMed Central
- PMC7538905
- Trial registry
- View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
- Funding
- Funding was not established from the accessible source; this is not a declaration of no funding.
- Competing interests
- The authors declared no competing interests in the publication.
Study snapshot
| Design | Multicenter double-blind four-arm randomized trial |
|---|---|
| Model | Human participants; see population |
| Sample | 409 participants completed randomized treatment |
| Intervention | Berberine, probiotics, combination or placebo after gentamicin run-in |
| Duration | 12 weeks |
| Endpoints | Fasting and postload glucose; HbA1c and insulin sensitivity; Lipid profile and tolerability |
What the study showed, in plain terms
Key findings
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