Tier 2 — strong

The efficacy and safety of berberine in combination with cinnamon supplementation in patients with type 2 diabetes: a randomized clinical trial

Mansour A, Sajjadi-Jazi SM, Gerami H, Khorasanian AS, Moalemzadeh B, Karimi S, Afrakoti NM, Mofid V, Mohajeri-Tehrani MR, Hekmatdoost A
European journal of nutrition 2025 64(2):102

Bibliography

PubMed
PMID 39998703
DOI
10.1007/s00394-025-03618-9
Funding
Indexed support: National Institute for Medical Research Development. See the publication for grant details.
Competing interests
A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Study snapshot

DesignDouble-blind randomized combination trial
ModelHuman participants; see population
SampleAdults with type 2 diabetes; denominator not specified in indexed abstract
InterventionBerberine 1200 mg/day plus cinnamon 600 mg/day versus placebo
Duration12 weeks
EndpointsFasting and postload glucose; HbA1c and insulin sensitivity; Lipid profile and tolerability

What the study showed, in plain terms

The combination improved fasting glucose, HbA1c and LDL cholesterol, while most other metabolic and anthropometric measures did not differ.

Key findings

  • The combination improved fasting glucose, HbA1c and LDL cholesterol, while most other metabolic and anthropometric measures did not differ.

What this study can and cannot tell us

No single-ingredient arms; the findings cannot establish berberine’s independent effect or synergy.

Source detail: indexed abstract and bibliographic record; unavailable methods or disclosures are identified rather than assumed.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology