Tier 4 — mechanistic

Combined berberine and probiotic treatment as an effective regimen for improving postprandial hyperlipidemia in type 2 diabetes patients: a double blinded placebo controlled randomized study

Wang S, Ren H, Zhong H, Zhao X, Li C, Ma J, Gu X, Xue Y, Huang S, Yang J, Chen L, Chen G, Qu S, Liang J, Qin L, Huang Q, Peng Y, Li Q, Wang X, Zou Y, Shi Z, Li X, Li T, Yang H, Lai S, Xu G, Li J, Zhang Y, Gu Y, Wang W
Gut microbes 2022 14(1):2003176

Bibliography

PubMed
PMID 34923903
PubMed Central
PMC8726654
DOI
10.1080/19490976.2021.2003176
Trial registry
View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
Funding
Indexed support: Shenzhen Municipal Government of China; the National Nature Science Foundation of China; Prevention and Control of Major Chronic Noncommunicable Diseases Research of China; the Program for Shanghai Outstanding Medical Academic Leader; National Key R&D Program of China. See the publication for grant details.
Competing interests
The authors declared no competing interests in the publication.

Study snapshot

DesignSecondary postprandial lipid analysis of PREMOTE
ModelHuman participants; see population
Sample365 PREMOTE participants with postprandial measurements
InterventionCompanion analysis of berberine/probiotic arms from PREMOTE
Duration3 months
EndpointsFasting and postload glucose; HbA1c and insulin sensitivity; Lipid profile and tolerability

What the study showed, in plain terms

This PREMOTE companion study examined post-meal lipids and microbial mechanisms. Combination treatment improved selected postprandial lipid measures.

Key findings

  • This PREMOTE companion study examined post-meal lipids and microbial mechanisms. Combination treatment improved selected postprandial lipid measures.

What this study can and cannot tell us

Same parent cohort as PMID 33024120. Cell-culture microbial experiments are distinct from human outcomes.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology