Tier 2 — strong

Inflammatory markers and noncoding-RNAs responses to low and high compressions of HIIT with or without berberine supplementation in middle-aged men with prediabetes

Nikseresht M, Dabidi Roshan V, Nasiri K, Nasiri K
Physiological reports 2024 12(15):e16146

Bibliography

PubMed
PMID 39107107
PubMed Central
PMC11303016
DOI
10.14814/phy2.16146
Funding
The authors reported no funding.
Competing interests
The authors declared no competing interests in the publication.

Study snapshot

DesignSix-arm randomized exercise and supplement study
ModelHuman participants; see population
Sample54 men across six arms
InterventionHIIT protocols with/without about 1 g/day berberine; supplement-only and control arms
Duration8 weeks
EndpointsFasting and postload glucose; HbA1c and insulin sensitivity; Lipid profile and tolerability

What the study showed, in plain terms

Exercise improved several metabolic and inflammatory measures. Adding berberine to the exercise programs did not demonstrate additional benefit.

Key findings

  • Exercise improved several metabolic and inflammatory measures. Adding berberine to the exercise programs did not demonstrate additional benefit.

What this study can and cannot tell us

Only about nine participants per arm; multiple comparisons and the reported glucose eligibility range complicate interpretation.

Related papers in the corpus

Tier 2
The efficacy and safety of berberine in combination with cinnamon supplementation in patients with type 2 diabetes: a randomized clinical trial
Mansour A et al. · European journal of nutrition · 2025
Tier 2
Efficacy and safety of HIMABERB® Berberine on glycemic control in patients with prediabetes: double-blind, placebo-controlled, and randomized pilot trial
Panigrahi A et al. · BMC endocrine disorders · 2023
Tier 2
Berberine phospholipid exerts a positive effect on the glycemic profile of overweight subjects with impaired fasting blood glucose (IFG): a randomized double-blind placebo-controlled clinical trial
Rondanelli M et al. · European review for medical and pharmacological sciences · 2023
Tier 2
Pilot study on the efficacy and safety of berberine in people with metabolic syndrome and human immunodeficiency virus infection
Ruiz-Herrera VV et al. · International journal of STD & AIDS · 2023
Tier 4
Combined berberine and probiotic treatment as an effective regimen for improving postprandial hyperlipidemia in type 2 diabetes patients: a double blinded placebo controlled randomized study
Wang S et al. · Gut microbes · 2022

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology