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Berberine phospholipid exerts a positive effect on the glycemic profile of overweight subjects with impaired fasting blood glucose (IFG): a randomized double-blind placebo-controlled clinical trial

Rondanelli M, Gasparri C, Petrangolini G, Allegrini P, Avenoso D, Fazia T, Bernardinelli L, Peroni G, Patelli Z, Mansueto F, Tartara A, Cavioni A, Riva A
European review for medical and pharmacological sciences 2023 27(14):6718-6727

Bibliography

PubMed
PMID 37522683
Funding
Funding was not established from the accessible source; this is not a declaration of no funding.
Competing interests
A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Study snapshot

DesignRandomized double-blind placebo-controlled formulation trial
ModelHuman participants; see population
Sample49 overweight adults with impaired fasting glucose
InterventionBerberine Phytosome: two 550-mg formulation tablets/day versus placebo
Duration60 days
EndpointsFasting and postload glucose; HbA1c and insulin sensitivity; Lipid profile and tolerability

What the study showed, in plain terms

A phospholipid formulation improved selected glycemic and lipid markers over two months. Tablet mass includes the formulation matrix and is not equivalent to isolated berberine mass.

Key findings

  • A phospholipid formulation improved selected glycemic and lipid markers over two months. Tablet mass includes the formulation matrix and is not equivalent to isolated berberine mass.

What this study can and cannot tell us

Small sample, multiple endpoints and formulation specificity; no long-term diabetes prevention endpoint.

Source detail: indexed abstract and bibliographic record; unavailable methods or disclosures are identified rather than assumed.

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