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Efficacy and safety of HIMABERB® Berberine on glycemic control in patients with prediabetes: double-blind, placebo-controlled, and randomized pilot trial

Panigrahi A, Mohanty S
BMC endocrine disorders 2023 23(1):190

Bibliography

PubMed
PMID 37679692
PubMed Central
PMC10483788
Funding
Funded by Siksha O Anusandhan; the authors reported no extramural funding.
Competing interests
The authors declared no known competing financial interests or personal relationships.

Study snapshot

DesignDouble-blind placebo-controlled randomized pilot
ModelHuman participants; see population
Sample34 adults with prediabetes
InterventionHIMABERB berberine 500 mg three times/day versus placebo
Duration12 weeks
EndpointsFasting and postload glucose; HbA1c and insulin sensitivity; Lipid profile and tolerability

What the study showed, in plain terms

This small commercial-formulation pilot reported improvements in glucose, HbA1c and insulin-resistance markers. It did not follow progression to diabetes.

Key findings

  • This small commercial-formulation pilot reported improvements in glucose, HbA1c and insulin-resistance markers. It did not follow progression to diabetes.

What this study can and cannot tell us

Small single trial and formulation-specific evidence. A biomarker below a threshold is not proof of durable diabetes prevention.

Citation network

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Editorial review

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