Effect of quercetin on the pharmacokinetics of rosiglitazone, a CYP2C8 substrate, in healthy subjects
Placebo-controlled crossover drug-interaction study. Rosiglitazone exposure and its metabolic ratio were similar with quercetin and placebo.
Quercetin Research Library — Records 261–290
Records 261–290 of 290. Open a study to inspect the full evidence record. Source links lead directly to the publication. Updated 19 October 2026.
Safety, interactions and special populations (4) · Kidney and cancer research (2) · Forms, absorption and food sources (14) · Prostate and urinary health (2) · Evidence reviews and human mechanisms (2) · Cardiovascular and metabolic health (3) · Skin and topical formulations (2) · Gut and intestinal health (1)
Safety, interactions and special populations
Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in humans
Pilot human supplementation study with ex vivo platelet assays. Platelet aggregation and selected collagen-signaling responses were reduced after ingestion.
Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: results from an in vitro and a dietary supplement study
Randomized dietary crossover study with supporting platelet experiments. Neither food intervention changed measured hemostatic outcomes, although high concentrations inhibited platelets in vitro.
Quercetin, an in vitro inhibitor of CYP3A, does not contribute to the interaction between nifedipine and grapefruit juice
Random-order human pharmacokinetic comparison. Grapefruit juice increased nifedipine exposure; quercetin did not, although absorption timing was delayed.
Kidney and cancer research
Beneficial effects of the bioflavonoids curcumin and quercetin on early function in cadaveric renal transplantation: a randomized placebo controlled trial
Randomized placebo-controlled renal-transplant trial. Early graft-function measures favored the combination, with lower creatinine in the higher-dose group.
Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition
Phase 1 intravenous oncology dose-escalation study. Tyrosine-phosphorylation inhibition was observed, and renal toxicity became dose limiting at high intravenous exposure.
Original sources: PubMed
Forms, absorption and food sources
Consumption of black currants, lingonberries and bilberries increases serum quercetin concentrations
Randomized parallel dietary intervention. Berry intake increased serum quercetin concentrations.
Plasma concentrations of the flavonoids hesperetin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables
Controlled crossover dietary biomarker study. Plasma quercetin did not change significantly between these dietary conditions, while citrus flavanone concentrations did.
Pre-clinical and clinical study of QC12, a water-soluble, pro-drug of quercetin
Early clinical pharmacokinetic study with supporting preclinical work. The oral prodrug produced no detectable plasma exposure; intravenous administration released measurable quercetin.
Pharmacokinetics and bioavailability of quercetin glycosides in humans
Four-way crossover human absorption study. Glucoside-containing treatments produced earlier, higher plasma conjugate concentrations than rutin-containing treatments; free quercetin was not detected.
Carbon dioxide is the major metabolite of quercetin in humans
Human radiolabeled disposition and mass-balance study. A substantial fraction of radiolabel appeared as exhaled carbon dioxide, showing extensive metabolism beyond urinary quercetin conjugates.
Bioavailabilities of quercetin-3-glucoside and quercetin-4'-glucoside do not differ in humans
Human crossover glucoside absorption comparison. The two glucosides had similar bioavailability and rapid peak concentrations.
Quercetin glucosides are completely hydrolyzed in ileostomy patients before absorption
Human ileostomy absorption and hydrolysis experiment. Intact glucosides were not detected in effluent; recovered aglycone supported extensive intestinal hydrolysis before absorption.
Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers
Double-blind diet-controlled crossover pharmacokinetic study. Aglycone was absorbed earlier; rutin had more variable absorption. Overall exposure was similar in this experiment, and metabolites predominated.
Absorption and antioxidant effects of quercetin from onions, in man
Acute dietary absorption and antioxidant pilot. Plasma quercetin and one antioxidant-capacity measure increased, but LDL oxidation susceptibility did not improve.
Effect of fruit juice intake on urinary quercetin excretion and biomarkers of antioxidative status
Crossover juice dose-response study. Urinary quercetin increased, while oxidative-stress measures showed mixed directions, including increased protein oxidation.
Plasma concentrations and urinary excretion of the antioxidant flavonols quercetin and kaempferol as biomarkers for dietary intake
Random-order crossover dietary biomarker study. Plasma and urinary flavonols reflected short-term intake; recovery differed between tea and onions.
Bioavailability of the dietary antioxidant flavonol quercetin in man
Human bioavailability synthesis describing dietary absorption experiments. Absorption and timing differed across glycosides and foods; onion-derived glucosides were absorbed more readily than rutin in the reported experiments.
Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers
Random-order crossover absorption study in ileostomy volunteers. Estimated intestinal absorption was higher from onion glucosides than rutin or aglycone under this method.
Disposition of quercetin in man after single oral and intravenous doses
Early human oral and intravenous disposition study. The older assay detected rapid intravenous disposition but no measurable oral plasma quercetin; fecal recovery suggested extensive gut metabolism.
Prostate and urinary health
Treatment of interstitial cystitis with a quercetin supplement
Open-label uncontrolled interstitial-cystitis pilot. Symptoms, problem scores, and global pain ratings improved from baseline.
Original sources: PubMed
Quercetin for chronic prostatitis/chronic pelvic pain syndrome
Clinical narrative review of chronic prostatitis/chronic pelvic pain syndrome. The review discusses quercetin as one possible component of multimodal chronic pelvic pain care.
Evidence reviews and human mechanisms
Dietary supplementation with the anti-tumour promoter quercetin: its effects on matrix metalloproteinase gene regulation
Placebo-controlled short-term human biomarker study. TIMP-1 expression and concentration decreased; MMP-2 and TIMP-2 did not change.
Effect of dietary quercetin on oxidative DNA damage in healthy human subjects
Randomized crossover dietary intervention. Plasma quercetin increased on the high-flavonol diet, but oxidative DNA damage in leukocytes did not decrease.
Original sources: PubMed
Cardiovascular and metabolic health
Quercetin intake and the incidence of cerebrovascular disease
Prospective observational dietary cohort. Quercetin intake was not associated with cerebrovascular disease incidence; an apple association was not explained by quercetin.
Nonalcoholic red wine extract and quercetin inhibit LDL oxidation without affecting plasma antioxidant vitamin and carotenoid concentrations
Randomized parallel supplementation comparison after a placebo run-in. Ex vivo LDL resistance to copper-induced oxidation increased; plasma lipid levels did not change.
Original sources: PubMed
Supplementation with quercetin markedly increases plasma quercetin concentration without effect on selected risk factors for heart disease in healthy subjects
Double-blind placebo-controlled supplementation study. Plasma quercetin rose markedly, but lipids, blood pressure, platelet measures, and other selected cardiovascular-risk markers did not improve.
Skin and topical formulations
Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration
Mouse topical intervention with single-cell and mechanistic analyses. Topical quercetin promoted hair-follicle regeneration in mice and altered follicular and vascular signatures.
Correction to: Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration
Published correction linked to the mouse hair-regeneration paper. The publication corrects the earlier hair-regeneration report and must be read alongside it.
Gut and intestinal health
Quercetin Protects Intestinal Barrier Integrity in Inflammation and Oxidative Stress
Dietary intervention and intestinal mechanism study in mice. Quercetin improved selected intestinal-barrier, inflammatory and signalling measures in high-fat-fed mice.
Design tiers organize different kinds of evidence; read the source-specific limitations before applying a result. The full library is curated by Biohack Blueprint. Each evidence record lists its editorial author and reviewers.