Tier 4 — mechanistic

Quercetin intake and the incidence of cerebrovascular disease

P Knekt, S Isotupa, H Rissanen, M Heliövaara, R Järvinen, S Häkkinen, A Aromaa, A Reunanen
European journal of clinical nutrition 2000 54(5):415-7

Bibliography

PubMed
PMID 10822289
DOI
10.1038/sj.ejcn.1600974
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignProspective observational dietary cohort
ModelHuman observational research
Sample9,208 Finnish adults; 824 cerebrovascular events
InterventionHabitual dietary quercetin intake
Duration28 years
EndpointsSource-specific outcomes described in the key findings

What the study showed, in plain terms

Published in 2000, this source examined cardiovascular and metabolic health. Design: Prospective observational dietary cohort. Sample/model: 9,208 Finnish adults; 824 cerebrovascular events. The exposure or intervention was Habitual dietary quercetin intake. Follow-up or treatment period: 28 years.

Quercetin intake was not associated with cerebrovascular disease incidence; an apple association was not explained by quercetin.

Older observational dietary data with possible measurement error and confounding. Whole-food associations cannot be converted into supplement-prevention claims.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin and Blood Pressure: How Large Is the Effect?. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Quercetin intake was not associated with cerebrovascular disease incidence; an apple association was not explained by quercetin.
  • The recorded outcome domains were Source-specific outcomes described in the key findings.
  • The exposure was observed rather than assigned as an isolated supplement treatment.

What this study can and cannot tell us

  • Older observational dietary data with possible measurement error and confounding. Whole-food associations cannot be converted into supplement-prevention claims.
  • Confounding, dietary patterns, illness, medication use and reverse causation can influence an association. Blood or dietary concentrations do not identify the effect of starting a capsule.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

Related papers in the corpus

Tier 1
The effects of Quercetin supplementation on cardiometabolic outcomes: An umbrella review of meta-analyses of randomized controlled trials
Seyyed Mostafa Arabi et al. · Phytotherapy research : PTR · 2023
Tier 1
The Effects of Quercetin Supplementation on Blood Pressure - Meta-Analysis
Joanna Popiolek-Kalisz et al. · Current problems in cardiology · 2022

Editorial review

Reviewed by the Biohack Blueprint research team

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology