Tier 2 — strong

Effect of dietary quercetin on oxidative DNA damage in healthy human subjects

E R Beatty, J D O'Reilly, T G England, G T McAnlis, I S Young, C A Geissler, T A Sanders, H Wiseman
The British journal of nutrition 2000 84(6):919

Bibliography

PubMed
PMID 11177210
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignRandomized crossover dietary intervention
ModelHuman intervention research
Sample36 healthy adults
InterventionHigh-flavonol onion cake and tea diet versus a low-flavonol diet
Duration14 days per diet; 14-day washout
EndpointsOxidative-stress measures; Exposure and pharmacokinetics

What the study showed, in plain terms

Published in 2000, this source examined evidence reviews and human mechanisms. Design: Randomized crossover dietary intervention. Sample/model: 36 healthy adults. The exposure or intervention was High-flavonol onion cake and tea diet versus a low-flavonol diet. Follow-up or treatment period: 14 days per diet; 14-day washout.

Plasma quercetin increased on the high-flavonol diet, but oxidative DNA damage in leukocytes did not decrease.

Food-based intervention rather than isolated quercetin. Increased blood concentration did not translate into the proposed DNA-protection effect.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin Benefits: What Human Studies Actually Show. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Plasma quercetin increased on the high-flavonol diet, but oxidative DNA damage in leukocytes did not decrease.
  • The recorded outcome domains were Oxidative-stress measures; Exposure and pharmacokinetics.
  • The result applies to the tested exposure: High-flavonol onion cake and tea diet versus a low-flavonol diet; 14 days per diet; 14-day washout.

What this study can and cannot tell us

  • Food-based intervention rather than isolated quercetin. Increased blood concentration did not translate into the proposed DNA-protection effect.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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D M Morrow et al. · Mutation research · 2001

Editorial review

Reviewed by the Biohack Blueprint research team

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology