Tier 2 — strong

Plasma concentrations of the flavonoids hesperetin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables

I Erlund, M L Silaste, G Alfthan, M Rantala, Y A Kesäniemi, A Aro
European journal of clinical nutrition 2002 56(9):891

Bibliography

PubMed
PMID 12209378
DOI
10.1038/sj.ejcn.1601409
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignControlled crossover dietary biomarker study
ModelHuman intervention research
Sample37 healthy women
InterventionDiets high or low in fruit and vegetables
Duration2-week baseline; two 5-week diets separated by 3 weeks
EndpointsExposure and pharmacokinetics

What the study showed, in plain terms

Published in 2002, this source examined forms, absorption and food sources. Design: Controlled crossover dietary biomarker study. Sample/model: 37 healthy women. The exposure or intervention was Diets high or low in fruit and vegetables. Follow-up or treatment period: 2-week baseline; two 5-week diets separated by 3 weeks.

Plasma quercetin did not change significantly between these dietary conditions, while citrus flavanone concentrations did.

Whole-diet study designed mainly around flavanones. It does not test isolated quercetin treatment or a clinical health outcome.

Continue with Quercetin Data Center

For topic-level interpretation, read Foods High in Quercetin: Practical Sources and Portions. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Plasma quercetin did not change significantly between these dietary conditions, while citrus flavanone concentrations did.
  • The recorded outcome domains were Exposure and pharmacokinetics.
  • The result applies to the tested exposure: Diets high or low in fruit and vegetables; 2-week baseline; two 5-week diets separated by 3 weeks.

What this study can and cannot tell us

  • Whole-diet study designed mainly around flavanones. It does not test isolated quercetin treatment or a clinical health outcome.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology