Tier 3 — preclinical

Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration

Qian Zhao, Yandong Zheng, Dongxin Zhao, Liyun Zhao, Lingling Geng, Shuai Ma, Yusheng Cai, Chengyu Liu, Yupeng Yan, Juan Carlos Izpisua Belmonte, Si Wang, Weiqi Zhang, Guang-Hui Liu, Jing Qu
Protein & cell 2023 14(6):398

Bibliography

PubMed
PMID 37285263
PubMed Central
PMC10246722
DOI
10.1093/procel/pwac062
Funding
Funding was not confirmed from the indexed record; consult the original publication.
Competing interests
The authors have no conflicts of interest to declare that are relevant to the content of this article and give their consent for the publication of this study.

Study snapshot

DesignMouse topical intervention with single-cell and mechanistic analyses
ModelAnimal or laboratory evidence
SampleMouse experiments and cellular analyses; exact model-specific sample sizes not confirmed in the indexed abstract
InterventionTopical quercetin in experimental mouse skin; not an oral human supplement
DurationExperimental treatment periods; exact regimen requires full methods
EndpointsModel-specific outcomes; see methods and findings

What the study showed, in plain terms

Published in 2023, this source examined skin and topical formulations. Design: Mouse topical intervention with single-cell and mechanistic analyses. Sample/model: Mouse experiments and cellular analyses; exact model-specific sample sizes not confirmed in the indexed abstract. The exposure or intervention was Topical quercetin in experimental mouse skin; not an oral human supplement. Follow-up or treatment period: Experimental treatment periods; exact regimen requires full methods.

Topical quercetin promoted hair-follicle regeneration in mice and altered follicular and vascular signatures.

Preclinical topical study. Oral human hair-growth efficacy was not tested. Read the linked 2025 correction with the original; the correction is not an independent study.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Skin and Hair: Oral vs Topical Evidence. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Topical quercetin promoted hair-follicle regeneration in mice and altered follicular and vascular signatures.
  • The recorded outcome domains were Model-specific outcomes; see methods and findings.
  • The result applies to the tested exposure: Topical quercetin in experimental mouse skin; not an oral human supplement; Experimental treatment periods; exact regimen requires full methods.

What this study can and cannot tell us

  • Preclinical topical study. Oral human hair-growth efficacy was not tested. Read the linked 2025 correction with the original; the correction is not an independent study.
  • Cell concentrations, species, disease models and experimental routes cannot be converted directly into an effective or safe oral human regimen.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this record. Missing method details, funding information or participant denominators are not inferred.

Related papers in the corpus

Correction to: Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration
et al. · Protein & cell · 2025
Tier 3
Quercetin as a therapeutic agent for skin problems: a systematic review and meta-analysis on antioxidant effects, oxidative stress, inflammation, wound healing, hyperpigmentation, aging, and skin cancer
Tia Okselni et al. · Naunyn-Schmiedeberg's archives of pharmacology · 2025

Citation network

Articles citing this research paper

1 article

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Editorial review

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology