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Absorption Kinetics of Berberine and Dihydroberberine and Their Impact on Glycemia: A Randomized, Controlled, Crossover Pilot Trial
Nutrients
2021
14(1):124
Bibliography
- PubMed
- PMID 35010998
- PubMed Central
- PMC8746601
- Funding
- Funded by NNB Nutrition.
- Competing interests
- One author was a paid adviser to NNB Nutrition; a conflict-management arrangement was reported.
Study snapshot
| Design | Double-blind randomized crossover pilot |
|---|---|
| Model | Human participants; see population |
| Sample | 5 healthy men |
| Intervention | Four-dose conditions: berberine 500 mg, dihydroberberine 100 or 200 mg, or placebo |
| Duration | Acute crossover with 2-hour sampling after the fourth dose |
| Endpoints | Plasma exposure and pharmacokinetics; Drug interaction measurements; Short-term tolerability |
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