Tier 2 — strong
Development of an Innovative Berberine Food-Grade Formulation with an Ameliorated Absorption: In Vitro Evidence Confirmed by Healthy Human Volunteers Pharmacokinetic Study
Evidence-based complementary and alternative medicine : eCAM
2021
2021:7563889
Bibliography
- PubMed
- PMID 34904017
- PubMed Central
- PMC8665891
- Funding
- Funding was not established from the accessible source; this is not a declaration of no funding.
- Competing interests
- All authors were employees of Indena, the formulation developer.
Study snapshot
| Design | Healthy-volunteer formulation pharmacokinetic study |
|---|---|
| Model | Human participants; see population |
| Sample | 12 healthy volunteers |
| Intervention | Berberine chloride 500 mg (452 mg berberine) versus Phytosome 550 or 1100 mg (188 or 376 mg berberine) |
| Duration | Acute crossover; sampling through 12 hours |
| Endpoints | Plasma exposure and pharmacokinetics; Drug interaction measurements; Short-term tolerability |
What the study showed, in plain terms
Key findings
What this study can and cannot tell us
Citation network
Articles citing this research paper
Biohack Blueprint analyses that reference this study in their evidence base.
- Best Berberine Supplements: Formulas, Testing and Value ComparedCompare the best berberine supplement options using official labels, testing claims, active amounts, current price context, safety and clear buying criteria.Read analysis
- Berberine Gummies vs Capsules: Dose, Ingredients and EvidenceBerberine gummies vs capsules and liquids: compare active doses, servings, ingredients, absorption claims, testing, cost and human evidence.Read analysis
- Berberine Phytosome vs Liposomal Berberine: Absorption ExplainedCompare berberine Phytosome, liposomal and micellar delivery. Understand active doses, absorption studies, clinical outcomes, tolerability and value.Read analysis
- Dihydroberberine vs Berberine: Absorption, Benefits and EvidenceDihydroberberine vs berberine: examine the five-person absorption pilot, glucose results, dose-equivalence claims, weight evidence and safety limits.Read analysis
- Berberine HCl: Hydrochloride, Plant Extracts and Label DifferencesWhat is berberine HCl? Understand hydrochloride, salt and extract amounts, 500 mg labels, enhanced formulations, human evidence and product quality.Read analysis
- Berberine vs Inositol: PCOS, Insulin Resistance and CombinationsCompare berberine vs inositol for PCOS, insulin resistance and weight. Understand trial limits, guideline advice, combination questions and safety.Read analysis
- Berberine for PCOS: Metabolic and Fertility Evidence ReassessedBerberine for PCOS reassessed: metabolic findings, the 2026 integrity review, live-birth trial, metformin and inositol comparisons, and pregnancy safety.Read analysis
- Berberine for Blood Sugar: Diabetes, Insulin Resistance and HbA1cReview berberine for blood sugar, HbA1c, insulin resistance and prediabetes. Compare controlled trials, real effect sizes, monitoring and safety.Read analysis
- Berberine During Pregnancy and Breastfeeding: Safety ExplainedBerberine pregnancy and breastfeeding safety: bilirubin concerns, PCOS pretreatment, inadvertent exposure, preconception questions and specialist guidance.Read analysis
- Berberine Interactions: Medicines, Supplements and AlcoholExplore demonstrated berberine interactions, CYP enzymes, cyclosporine, diabetes medicines, statins, thyroid questions, supplements and alcohol.Read analysis
- Berberine Side Effects: Digestive Symptoms and Long-Term SafetyUnderstand berberine side effects, digestive complaints, glucose concerns, heart-rhythm reports, long-term safety limits and when to seek medical help.Read analysis
- Best Time to Take Berberine: Meals, Morning or Night?When should you take berberine? Compare meal instructions, morning and bedtime use, divided doses, fasting questions and medicine-spacing limitations.Read analysis
Editorial review
Reviewed by the Biohack Blueprint research team
Last verified
