Tier 2 — strong
Repeated administration of berberine inhibits cytochromes P450 in humans
European journal of clinical pharmacology
2012
68(2):213-217
Bibliography
- PubMed
- PMID 21870106
- PubMed Central
- PMC4898966
- Funding
- Indexed support: NIDDK NIH HHS; NCRR NIH HHS; NIEHS NIH HHS. See the publication for grant details.
- Competing interests
- A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.
Study snapshot
| Design | Randomized crossover CYP-probe study |
|---|---|
| Model | Human participants; see population |
| Sample | Healthy men in a two-period crossover study |
| Intervention | Berberine 300 mg three times/day followed by CYP probe drugs |
| Duration | 14 days |
| Endpoints | Plasma exposure and pharmacokinetics; Drug interaction measurements; Short-term tolerability |
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