Tier 3 — preclinical
Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action
Diabetes
2008
57(5):1414-1418
Bibliography
- PubMed
- PMID 18285556
- Funding
- Funding was not established from the accessible source; this is not a declaration of no funding.
- Competing interests
- A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.
Study snapshot
| Design | Animal and/or cellular experimental study |
|---|---|
| Model | Muscle-cell models, isolated mitochondria and high-fat-fed rodents |
| Sample | Myotube/mitochondrial experiments and high-fat-fed rodents |
| Intervention | Berberine and dihydroberberine with respiratory-chain measurements |
| Duration | Experimental periods vary by assay |
| Endpoints | Cellular or animal mechanisms; Model-specific outcomes; Route and exposure |
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