Tier 3 — preclinical
Berberine Extends Lifespan in C. elegans Through Multi-Target Synergistic Antioxidant Effects
Antioxidants (Basel, Switzerland)
2025
14(4):450
Bibliography
- PubMed
- PMID 40338239
- PubMed Central
- PMC12024168
- Funding
- The authors reported no external funding.
- Competing interests
- The authors declared no conflicts of interest.
Study snapshot
| Design | Animal and/or cellular experimental study |
|---|---|
| Model | Caenorhabditis elegans wild-type and genetic strains |
| Sample | Wild-type, mutant and transgenic nematode populations |
| Intervention | Berberine exposure in worm lifespan/stress assays |
| Duration | Worm lifespan and stress-response experiments |
| Endpoints | Worm mean lifespan; Stress resistance and locomotion; Antioxidant and transcriptomic responses |
What the study showed, in plain terms
Key findings
What this study can and cannot tell us
Citation network
Articles citing this research paper
Biohack Blueprint analyses that reference this study in their evidence base.
- Berberine, AMPK and Longevity: Mechanisms vs Human OutcomesBerberine longevity evidence: AMPK, mitochondrial mechanisms, mouse and worm lifespan studies, senescence claims, human outcomes and supplement stacks.Read analysis
- Berberine Benefits: What Human Studies Actually ShowExplore berberine benefits for blood sugar, cholesterol, weight and gut health, with human trial results, 2026 updates, safety and formulation differences.Read analysis
Editorial review
Reviewed by the Biohack Blueprint research team
Last verified
