Tier 3 — preclinical
Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression
Aging cell
2020
19(1):e13060
Bibliography
- PubMed
- PMID 31773901
- PubMed Central
- PMC6974710
- Funding
- Indexed support: National key research and development program of China; National Natural Science Foundation of China; PKU Fund for Fostering Young Scholars; Natural Science Foundation of Beijing Municipality. See the publication for grant details.
- Competing interests
- The publication contains author disclosures. Commercial relationships, employment, funding or other interests should be interpreted from the complete declaration; it is not classified here as conflict-free.
Study snapshot
| Design | Animal and/or cellular experimental study |
|---|---|
| Model | 2BS/WI38 fibroblasts and naturally aged or chemotherapy-treated mice |
| Sample | Human fibroblast cultures and aged/chemotherapy-treated mice |
| Intervention | Berberine in cell culture and oral mouse treatment |
| Duration | Cell lifespan and residual mouse-survival experiments |
| Endpoints | Cellular senescence and cell-cycle markers; Mouse lifespan/residual survival; Experimental health measures |
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