Tier 2 — strong
Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study
European journal of clinical pharmacology
2005
61(8):567-572
Bibliography
- PubMed
- PMID 16133554
- Funding
- Funding was not established from the accessible source; this is not a declaration of no funding.
- Competing interests
- A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.
Study snapshot
| Design | Controlled transplant interaction trial plus pharmacokinetic substudy |
|---|---|
| Model | Human participants; see population |
| Sample | 104 renal-transplant recipients; separate six-person PK component |
| Intervention | Berberine 200 mg three times/day with cyclosporine versus cyclosporine alone |
| Duration | 3 months; separate 12-day PK assessment |
| Endpoints | Plasma exposure and pharmacokinetics; Drug interaction measurements; Short-term tolerability |
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