Tier 4 — mechanistic

Variability in Potency Among Commercial Preparations of Berberine

Funk RS, Singh RK, Winefield RD, Kandel SE, Ruisinger JF, Moriarty PM, Backes JM
Journal of dietary supplements 2018 15(3):343-351

Bibliography

PubMed
PMID 28792254
PubMed Central
PMC5807210
Funding
Indexed support: NIGMS NIH HHS. See the publication for grant details.
Competing interests
A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Study snapshot

DesignCommercial product-potency analytical study
ModelCommercial supplement samples
Sample15 commercial products; 3 capsules assayed per product
InterventionAnalytical measurement of berberine content against label claims
DurationOne market sampling/assay study
EndpointsMeasured berberine content against label claim; Capsule/product variability; Association between cost and potency

What the study showed, in plain terms

Berberine content varied substantially across this historical product sample. Price did not reliably predict measured potency.

Key findings

  • Mean measured content was about 75% of label claim, with a range of 33–100%.
  • Nine of fifteen products fell below the study’s 90% lower potency benchmark.

What this study can and cannot tell us

A snapshot of products and lots at the time; cannot rank current brands or establish the quality of an untested product.

Source detail: indexed abstract and bibliographic record; unavailable methods or disclosures are identified rather than assumed.

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