Tier 4 — mechanistic

Recurrent Torsades de Pointes Precipitated by Berberine Supplement

Mohammadi A, Abdalla HM, Falls N, Tan MC, Kanaan CN, Sorajja D, Cannan CR, Sardana M, El Masry HZ
JACC. Case reports 2026 :110193

Bibliography

PubMed
PMID 42684237
DOI
10.1016/j.jaccas.2026.110193
Funding
Funding was not established from the accessible source; this is not a declaration of no funding.
Competing interests
A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Study snapshot

DesignClinical arrhythmia case report
ModelHuman participants; see population
Sample1 man aged 61
InterventionSeveral supplements including berberine, dihydroberberine, turmeric and quercetin
DurationExposure before recurrent torsades; follow-up after withdrawal
EndpointsQTc and recurrent torsades; Electrolytes and genetic investigation; Course after stopping multiple supplements

What the study showed, in plain terms

A patient developed marked QT prolongation and recurrent torsades while using several supplements, with mild hypomagnesemia. QT normalized after management and supplement withdrawal.

Key findings

  • A patient developed marked QT prolongation and recurrent torsades while using several supplements, with mild hypomagnesemia. QT normalized after management and supplement withdrawal.

What this study can and cannot tell us

Multiple exposures and electrolyte disturbance prevent assigning causation to one ingredient. This report cannot quantify risk.

Source detail: indexed abstract and bibliographic record; unavailable methods or disclosures are identified rather than assumed.

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Displacement of bilirubin from albumin by berberine
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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology