Tier 4 — mechanistic

Dietary choline and betaine and the risk of distal colorectal adenoma in women

Eunyoung Cho, Walter C Willett, Graham A Colditz, Charles S Fuchs, Kana Wu, Andrew T Chan, Steven H Zeisel, Edward L Giovannucci
Journal of the National Cancer Institute 2007 99(16):1224-1231

Bibliography

PubMed
PMID 17686825
PubMed Central
PMC2441932
DOI
10.1093/jnci/djm082
Funding
Indexed grant support: CA108341 — NCI NIH HHS — United States; P30 DK040561 — NIDDK NIH HHS — United States; DK55865 — NIDDK NIH HHS — United States; P01 CA087969 — NCI NIH HHS — United States; R01 DK055865 — NIDDK NIH HHS — United States; CA87969 — NCI NIH HHS — United States; P30 DK056350 — NIDDK NIH HHS — United States; R03 CA108341 — NCI NIH HHS — United States; DK56350 — NIDDK NIH HHS — United States. The indexed list may not contain the complete funding declaration.
Competing interests
A competing-interest declaration was not available in the indexed record or accessible disclosure metadata.

Study snapshot

DesignProspective endoscopy cohort
ModelHuman participants
Sample39246 women; 2408 adenoma cases
InterventionHabitual dietary choline and/or betaine intake; no randomized TMG treatment
Duration1984-2002
EndpointsColorectal adenoma

What the study showed, in plain terms

Published in 2007, this source examined human observational and biomarker research. It examined Habitual dietary choline and/or betaine intake; no randomized TMG treatment. The source describes 39246 women; 2408 adenoma cases.

Betaine intake had a nonlinear inverse association with adenoma; the highest-versus-lowest comparison and overall trend were not clearly significant.

Observational exposure analysis: residual confounding and reverse causation remain possible. Associations do not establish that betaine supplementation causes the same outcome.

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Key findings

  • Betaine intake had a nonlinear inverse association with adenoma; the highest-versus-lowest comparison and overall trend were not clearly significant.
  • The recorded outcome domains were Colorectal adenoma.

What this study can and cannot tell us

  • Observational exposure analysis: residual confounding and reverse causation remain possible. Associations do not establish that betaine supplementation causes the same outcome.
  • Source basis: Indexed abstract and bibliographic data. Missing method details, funding information or participant denominators are not inferred.

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Editorial review

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology