Tier 4 — mechanistic

Association of choline and betaine levels with cancer incidence and survival: A meta-analysis

Jiyoung Youn, Eunyoung Cho, Jung Eun Lee
Clinical nutrition (Edinburgh, Scotland) 2019 38(1):100-109

Bibliography

PubMed
PMID 29606601
DOI
10.1016/j.clnu.2018.01.042
Funding
Funding was not specified in the indexed record or accessible funding metadata.
Competing interests
A competing-interest declaration was not available in the indexed record or accessible disclosure metadata.

Study snapshot

DesignMeta-analysis of observational studies
ModelEvidence synthesis; mixed research models
Sample28 observational studies overall
InterventionDietary or circulating choline and betaine
DurationSearch through January 2018
EndpointsCancer incidence; Cancer survival

What the study showed, in plain terms

Published in 2019, this source examined safety assessments and evidence synthesis. Its evidence base was 28 observational studies overall. It evaluated Dietary or circulating choline and betaine across Search through January 2018.

Higher betaine exposure was associated with somewhat lower cancer incidence, especially colorectal cancer; survival associations were not significant.

Dietary and blood measures are different exposures. Observational synthesis does not demonstrate prevention or treatment by TMG supplements.

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Key findings

  • Higher betaine exposure was associated with somewhat lower cancer incidence, especially colorectal cancer; survival associations were not significant.
  • The recorded outcome domains were Cancer incidence; Cancer survival.

What this study can and cannot tell us

  • Dietary and blood measures are different exposures. Observational synthesis does not demonstrate prevention or treatment by TMG supplements.
  • Observational human evidence synthesis. Pooling associations does not convert dietary intake or circulating biomarkers into a randomized effect of taking TMG.
  • Source basis: Indexed abstract and bibliographic data. Missing method details, funding information or participant denominators are not inferred.

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Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology