Tier 4 — mechanistic

The association between dietary intakes of methionine, choline and betaine and breast cancer risk: A systematic review and meta-analysis

Heleen Van Puyvelde, Niki Dimou, Aikaterini Katsikari, Blanca Iciar Indave Ruiz, Lode Godderis, Inge Huybrechts, Dirk De Bacquer
Cancer epidemiology 2023 83:102322

Bibliography

PubMed
PMID 36701983
DOI
10.1016/j.canep.2023.102322
Funding
Indexed grant support: 001 — World Health Organization — International. The indexed list may not contain the complete funding declaration.
Competing interests
Reported disclosure: Disclosure of interest The authors report no conflict of interest.

Study snapshot

DesignSystematic review and meta-analysis of observational studies
ModelEvidence synthesis; mixed research models
Sample21 studies reviewed; 18 included in meta-analyses
InterventionDietary methionine, choline and betaine
DurationSearch through July 2022
EndpointsBreast-cancer risk

What the study showed, in plain terms

Published in 2023, this source examined safety assessments and evidence synthesis. Its evidence base was 21 studies reviewed; 18 included in meta-analyses. It evaluated Dietary methionine, choline and betaine across Search through July 2022.

The analysis found little clear evidence that dietary betaine was associated with breast-cancer risk.

Imprecise estimates and limited studies; earlier broad cancer findings should not be generalized to breast-cancer prevention.

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Key findings

  • The analysis found little clear evidence that dietary betaine was associated with breast-cancer risk.
  • The recorded outcome domains were Breast-cancer risk.

What this study can and cannot tell us

  • Imprecise estimates and limited studies; earlier broad cancer findings should not be generalized to breast-cancer prevention.
  • Observational human evidence synthesis. Pooling associations does not convert dietary intake or circulating biomarkers into a randomized effect of taking TMG.
  • Source basis: Indexed abstract and bibliographic data. Missing method details, funding information or participant denominators are not inferred.

Related papers in the corpus

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Association of choline and betaine levels with cancer incidence and survival: A meta-analysis
Jiyoung Youn et al. · Clinical nutrition (Edinburgh, Scotland) · 2019
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Serum betaine but not choline is inversely associated with breast cancer risk: a case-control study in China
Yu-Feng Du et al. · European journal of nutrition · 2017
Tier 1
Effects of betaine supplementation on cardiovascular markers: A systematic review and Meta-analysis
Damoon Ashtary-Larky et al. · Critical reviews in food science and nutrition · 2022
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Betaine Supplementation Moderately Increases Total Cholesterol Levels: A Systematic Review and Meta-Analysis
Emilia E Zawieja et al. · Journal of dietary supplements · 2021
Tier 2
Safety of betaine as a novel food pursuant to Regulation (EC) No 258/97
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) et al. · EFSA journal. European Food Safety Authority · 2017
Tier 2
Safety of betaine as a novel food pursuant to Regulation (EU) 2015/2283
EFSA Panel on Nutrition, Novel Foods and Food Allergens (EFSA NDA Panel) et al. · EFSA journal. European Food Safety Authority · 2019

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology