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Overall and Sex-Specific Effect of Berberine for the Treatment of Dyslipidemia in Adults: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials

Blais JE, Huang X, Zhao JV
Drugs 2023 83(5):403-427

Bibliography

PubMed
PMID 36941490
Funding
Funding was not established from the accessible source; this is not a declaration of no funding.
Competing interests
A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Study snapshot

DesignSystematic review and meta-analysis
ModelPublished human studies
Sample18 studies; 1788 participants
InterventionEvidence synthesis; interventions and comparators vary across included studies
DurationNo new treatment; included-study durations vary
EndpointsPooled clinical or metabolic outcomes; Risk of bias and heterogeneity; Adverse-event reporting

What the study showed, in plain terms

The placebo-controlled synthesis estimated lower LDL cholesterol, total cholesterol, triglycerides and apoB, with a small HDL increase.

Key findings

  • The placebo-controlled synthesis estimated lower LDL cholesterol, total cholesterol, triglycerides and apoB, with a small HDL increase.

What this study can and cannot tell us

Mostly Chinese/Hong Kong populations and 4–24-week studies; long-term event prevention and rare harms remain uncertain.

Source detail: indexed abstract and bibliographic record; unavailable methods or disclosures are identified rather than assumed.

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