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The Integrative Role of Berberine in Gut Microbiota Modulation and Cardiometabolic Outcomes: A Systematic Review of Randomised Clinical Trials

Candrea AR, Gavrilaș LI, Frumuzachi O, Mocan A, Babotă M, Crișan G

Nutrients 2026 18(12):1858

Bibliography

PubMed: PMID 42356246
PubMed Central: PMC13305239
DOI: 10.3390/nu18121858
Funding: Funding was not established from the accessible source; this is not a declaration of no funding.
Competing interests: A complete competing-interest declaration was not available in the accessible source; no absence of conflicts is inferred.

Design	Systematic review and meta-analysis
Model	Published human studies
Sample	7 randomized trials
Intervention	Evidence synthesis; interventions and comparators vary across included studies
Duration	No new treatment; included-study durations vary
Endpoints	Pooled clinical or metabolic outcomes; Risk of bias and heterogeneity; Adverse-event reporting

Most included trials found microbiota changes alongside metabolic findings. The review notes that compositional changes were not uniformly favorable.

Most included trials found microbiota changes alongside metabolic findings. The review notes that compositional changes were not uniformly favorable.

Concurrent microbial and metabolic changes do not establish causal mediation or a universally healthier microbiome.

Editorial review

Last verified 22 October 2026