Tier 2 — strong

Effect of low-dose supplements of menaquinone-7 (vitamin K2 ) on the stability of oral anticoagulant treatment: dose-response relationship in healthy volunteers

E Theuwissen, K J Teunissen, H M H Spronk, K Hamulyák, H Ten Cate, M J Shearer, C Vermeer, L J Schurgers
Journal of thrombosis and haemostasis : JTH 2013 11(6):1085-92

Bibliography

PubMed
PMID 23530987
DOI
10.1111/jth.12203
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignControlled dose-escalation anticoagulant-interaction study
ModelHuman participants
Sample18 volunteers enrolled; 15 reached the target anticoagulation level
InterventionMK-7 10, 20 and 45 μg/day during acenocoumarol therapy
Duration4-week anticoagulation lead-in followed by 6-week dose escalation
EndpointsINR; Coagulation biomarkers; Thrombin generation

What the study showed, in plain terms

This publication examines inr, coagulation biomarkers, thrombin generation. Study population or evidence base: 18 volunteers enrolled; 15 reached the target anticoagulation level. Intervention or exposure: MK-7 10, 20 and 45 μg/day during acenocoumarol therapy.

Key findings

MK-7 reduced sensitivity to a vitamin K antagonist, with clinically relevant INR effects in some volunteers even at low supplemental doses.

What this study can and cannot tell us

A small controlled pharmacodynamic study using acenocoumarol. Its relevance is specifically to vitamin K antagonist therapy, rather than all anticoagulant medicines.

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