Tier 2 — strong

US Pharmacopeial Convention safety evaluation of menaquinone-7, a form of vitamin K

Robin J Marles, Amy L Roe, Hellen A Oketch-Rabah
Nutrition reviews 2017 75(7):553-578

Bibliography

PubMed
PMID 28838081
DOI
10.1093/nutrit/nux022
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignSafety evaluation and narrative evidence review
ModelHuman evidence synthesis
SampleMultiple clinical and nonclinical reports; no single intervention cohort
InterventionMK-7 across the doses and formulations reviewed
DurationVaried across reviewed studies
EndpointsToxicology; Clinical adverse events; Pharmacokinetics; Ingredient quality

What the study showed, in plain terms

This publication examines toxicology, clinical adverse events, pharmacokinetics, ingredient quality. Study population or evidence base: Multiple clinical and nonclinical reports; no single intervention cohort. Intervention or exposure: MK-7 across the doses and formulations reviewed.

Key findings

The USP evaluation found no major general safety concern from the evidence it reviewed and described quality standards for MK-7 ingredients and dosage forms.

What this study can and cannot tell us

A safety review, not a trial of efficacy or proof that every commercial product meets USP standards. Vitamin K antagonist interactions require separate consideration.

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