Tier 1 — highest

The study of bioavailability and endogenous circadian rhythm of menaquinone-7, a form of vitamin K2, in healthy subjects

Fan Du, Min Yan, Lili Duan, Guolong Xie, Xiuhua Yao, Wenjing Hu, Yu Liu, Min Meng, Jiepeng Chen, Di Shao
The British journal of nutrition 2023 130(11):1885-1897

Bibliography

PubMed
PMID 37132123
DOI
10.1017/S0007114523001034
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
SampleTwo pharmacokinetic studies involving 5 and 12 healthy men
InterventionSingle fasting MK-7 dose of 1 mg
DurationSingle-dose pharmacokinetic monitoring
EndpointsPlasma MK-7 concentrations; Absorption and elimination; Circadian variation

What the study showed, in plain terms

This publication examines plasma mk-7 concentrations, absorption and elimination, circadian variation. Study population or evidence base: Two pharmacokinetic studies involving 5 and 12 healthy men. Intervention or exposure: Single fasting MK-7 dose of 1 mg.

Key findings

MK-7 reached peak plasma concentrations at approximately six hours and showed prolonged persistence. The small endogenous-rhythm experiment found no clear circadian pattern.

What this study can and cannot tell us

Small male-only studies at a relatively high single dose. They do not determine an optimal daily supplement dose or prove a preferred time of day.

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