Tier 1 — highest

Steady-state vitamin K2 (menaquinone-7) plasma concentrations after intake of dairy products and soft gel capsules

M H J Knapen, L A J L M Braam, K J Teunissen, C M Van't Hoofd, R M L Zwijsen, E G H M van den Heuvel, C Vermeer
European journal of clinical nutrition 2016 70(7):831-6

Bibliography

PubMed
PMID 26908424
DOI
10.1038/ejcn.2016.3
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
SampleHealthy men and postmenopausal women aged 45–65
InterventionMK-7 in fortified yogurt, nutrient-enriched yogurt or softgel capsules
Duration42 days, followed by 2-week washout
EndpointsPlasma MK-7; Vitamin D status; Vitamin K-status biomarkers

What the study showed, in plain terms

This publication examines plasma mk-7, vitamin d status, vitamin k-status biomarkers. Study population or evidence base: Healthy men and postmenopausal women aged 45–65. Intervention or exposure: MK-7 in fortified yogurt, nutrient-enriched yogurt or softgel capsules.

Key findings

All delivery approaches improved vitamin K biomarkers. The nutrient-enriched yogurt produced higher circulating MK-7 than capsules, suggesting a food-matrix effect.

What this study can and cannot tell us

A small delivery-form study; the abstract does not state the full sample or MK-7 dose. It cannot isolate individual effects of D3, magnesium or the other added nutrients.

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