Tier 2 — strong

Vitamin K2 (Menaquinone-7) supplementation does not affect vitamin K-dependent coagulation factors activity in healthy individuals

Ruijun Ren, Jia Liu, Guo Cheng, Jing Tan
Medicine 2021 100(23):e26221

Bibliography

PubMed
PMID 34115006
PubMed Central
PMC8202544
DOI
10.1097/MD.0000000000026221
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
The authors report no relevant competing interests.

Study snapshot

DesignProspective single-arm supplementation study
ModelHuman participants
Sample40 healthy adults aged 25–40
InterventionMK-7 90 μg/day
Duration30 days
EndpointsCoagulation times; Activities of factors II, VII, IX and X; PIVKA-II

What the study showed, in plain terms

This publication examines coagulation times, activities of factors ii, vii, ix and x, pivka-ii. Study population or evidence base: 40 healthy adults aged 25–40. Intervention or exposure: MK-7 90 μg/day.

Key findings

The study found no significant changes in measured coagulation times or vitamin K-dependent clotting-factor activity after one month of MK-7.

What this study can and cannot tell us

No placebo group, a small sample and short follow-up. Healthy participants were not taking anticoagulants, so these results do not resolve vitamin K antagonist interactions.

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