Tier 4 — mechanistic

Carboxylative efficacy of trans and cis MK7 and comparison with other vitamin K isomers

Ilenia Cirilli, Patrick Orlando, Sonia Silvestri, Fabio Marcheggiani, Phiwayinkosi V Dludla, Nadine Kaesler, Luca Tiano
BioFactors (Oxford, England) 2022 48(5):1129-1136

Bibliography

PubMed
PMID 35583412
PubMed Central
PMC9790681
DOI
10.1002/biof.1844
Funding
Support is recorded from German Research Foundation, Deutsche Forschungsgemeinschaft (DFG, German Research Foundation). See the original publication for grant and material-support details.
Competing interests
The authors report no relevant competing interests.

Study snapshot

DesignLaboratory comparison using protein and cell-free enzyme assays
ModelIn vitro and cell-free experimental systems
SampleLaboratory assays; no human clinical cohort
InterventionTrans and cis MK-7 and comparator vitamin K forms in experimental assays
DurationLaboratory assay exposure
Endpointsγ-Glutamylcarboxylase activity; Gla-protein carboxylation

What the study showed, in plain terms

This publication examines γ-glutamylcarboxylase activity, gla-protein carboxylation. Study population or evidence base: Laboratory assays; no human clinical cohort. Intervention or exposure: Trans and cis MK-7 and comparator vitamin K forms in experimental assays.

Key findings

Trans MK-7 showed stronger carboxylation activity than the cis isomer in the experimental systems, providing a mechanistic reason to distinguish ingredient isomers.

What this study can and cannot tell us

Laboratory activity does not quantify comparative clinical benefit or establish the isomer composition of any retail product.

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