Tier 1 — highest

Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women

Toshiro Sato, Leon J Schurgers, Kazuhiro Uenishi
Nutrition journal 2012 11:93

Bibliography

PubMed
PMID 23140417
PubMed Central
PMC3502319
DOI
10.1186/1475-2891-11-93
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
The authors report no relevant competing interests.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
SampleHealthy Japanese women in single-dose and repeated-dose experiments
InterventionMK-4 or MK-7: 420 μg once, and 60 μg/day for 7 days
DurationSingle-dose monitoring and 7-day supplementation
EndpointsSerum MK-4 and MK-7 concentrations

What the study showed, in plain terms

This publication examines serum mk-4 and mk-7 concentrations. Study population or evidence base: Healthy Japanese women in single-dose and repeated-dose experiments. Intervention or exposure: MK-4 or MK-7: 420 μg once, and 60 μg/day for 7 days.

Key findings

MK-7 produced measurable, sustained blood concentrations, whereas nutritional-dose MK-4 was not detectably increased using the study's assay and sampling schedule.

What this study can and cannot tell us

Small pharmacokinetic experiments measure circulating exposure, not clinical superiority. Undetectable serum MK-4 does not by itself prove no tissue activity.

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