Tier 1 — highest

The combination effect of vitamin K and vitamin D on human bone quality: a meta-analysis of randomized controlled trials

Xiaotong Kuang, Chunxiao Liu, Xiaofei Guo, Kelei Li, Qingxue Deng, Duo Li
Food & function 2020 11(4):3280-3297

Bibliography

PubMed
PMID 32219282
DOI
10.1039/c9fo03063h
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignSystematic review and meta-analysis
ModelHuman evidence synthesis
Sample8 randomized trials involving 971 participants
InterventionVitamin K plus vitamin D, with differing forms, doses and control treatments
DurationVaried across included trials
EndpointsBone mineral density; Undercarboxylated osteocalcin

What the study showed, in plain terms

This publication examines bone mineral density, undercarboxylated osteocalcin. Study population or evidence base: 8 randomized trials involving 971 participants. Intervention or exposure: Vitamin K plus vitamin D, with differing forms, doses and control treatments.

Key findings

Pooling the trials favored combined vitamin K and D for bone mineral density and osteocalcin carboxylation. The review supports studying complementary nutrient roles in bone health.

What this study can and cannot tell us

The analysis combines different vitamin K forms, populations and regimens. Bone-density and biochemical effects do not establish fracture prevention or the performance of a particular combined product.

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