Tier 1 — highest

Beneficial effects of vitamins D and K on the elastic properties of the vessel wall in postmenopausal women: a follow-up study

Lavienja A J L M Braam, Arnold P G Hoeks, Fred Brouns, Karly Hamulyák, Monique J W Gerichhausen, Cees Vermeer
Thrombosis and haemostasis 2004 91(2):373-80

Bibliography

PubMed
PMID 14961167
DOI
10.1160/TH03-07-0423
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample181 women randomized; vascular analysis included 108 participants
InterventionMinerals plus vitamin D with or without vitamin K1, compared with placebo
Duration3 years
EndpointsCarotid artery elasticity; Pulse pressure; Intima-media thickness

What the study showed, in plain terms

This publication examines carotid artery elasticity, pulse pressure, intima-media thickness. Study population or evidence base: 181 women randomized; vascular analysis included 108 participants. Intervention or exposure: Minerals plus vitamin D with or without vitamin K1, compared with placebo.

Key findings

Arterial elastic properties were better preserved in the group receiving vitamin K1 with minerals and vitamin D. Intima-media thickness did not significantly differ.

What this study can and cannot tell us

This study used K1, not K2. Attrition and the smaller analyzed sample limit interpretation, and vascular elasticity is not a clinical cardiovascular-event outcome.

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