Tier 1 — highest

Vitamin K supplement along with vitamin D and calcium reduced serum concentration of undercarboxylated osteocalcin while increasing bone mineral density in Korean postmenopausal women over sixty-years-old

Sang Hyeon Je, Nam-Seok Joo, Beom-hee Choi, Kwang-Min Kim, Bom-Taeck Kim, Sat-Byul Park, Doo-Yeoun Cho, Kyu-Nam Kim, Duck-Joo Lee
Journal of Korean medical science 2011 26(8):1093-8

Bibliography

PubMed
PMID 21860562
PubMed Central
PMC3154347
DOI
10.3346/jkms.2011.26.8.1093
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample78 women enrolled; 45 completed and were included in the per-protocol analysis
InterventionMK-4 45 mg/day plus vitamin D 400 IU/day and calcium 630 mg/day, versus D plus calcium
Duration6 months
EndpointsLumbar bone mineral density; Undercarboxylated osteocalcin

What the study showed, in plain terms

This publication examines lumbar bone mineral density, undercarboxylated osteocalcin. Study population or evidence base: 78 women enrolled; 45 completed and were included in the per-protocol analysis. Intervention or exposure: MK-4 45 mg/day plus vitamin D 400 IU/day and calcium 630 mg/day, versus D plus calcium.

Key findings

Adding high-dose MK-4 reduced undercarboxylated osteocalcin and improved bone density at the L3 vertebra compared with vitamin D and calcium alone.

What this study can and cannot tell us

Substantial attrition, per-protocol analysis and short follow-up reduce certainty. The high-dose MK-4 regimen is different from nutritional-dose MK-7.

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