Tier 1 — highest

Effect of supplementation with vitamins D3 and K2 on undercarboxylated osteocalcin and insulin serum levels in patients with type 2 diabetes mellitus: a randomized, double-blind, clinical trial

J I Aguayo-Ruiz, T A García-Cobián, S Pascoe-González, S Sánchez-Enríquez, I M Llamas-Covarrubias, T García-Iglesias, A López-Quintero, M A Llamas-Covarrubias, J Trujillo-Quiroz, E A Rivera-Leon
Diabetology & metabolic syndrome 2020 12:73

Bibliography

PubMed
PMID 32831908
PubMed Central
PMC7436967
DOI
10.1186/s13098-020-00580-w
Trial registry
View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
Funding
Support is recorded from Secretaría de Educación Pública, Mexico. See the original publication for grant and material-support details.
Competing interests
The authors report no relevant competing interests.

Study snapshot

DesignRandomized, double-blind, three-arm clinical trial
ModelHuman participants
Sample40 adults with type 2 diabetes
InterventionD3 1,000 IU/day, K2 100 μg/day, or their combination
Duration3 months
EndpointsOsteocalcin carboxylation; Glucose and insulin measures; HOMA-IR

What the study showed, in plain terms

This publication examines osteocalcin carboxylation, glucose and insulin measures, homa-ir. Study population or evidence base: 40 adults with type 2 diabetes. Intervention or exposure: D3 1,000 IU/day, K2 100 μg/day, or their combination.

Key findings

The study reported improvements in glucose and selected osteocalcin measures within the active-treatment groups. It explored links between vitamin status, bone biomarkers and metabolism.

What this study can and cannot tell us

Small unequal groups and no untreated double-placebo arm. Within-group changes do not establish that the combination is superior or that vitamin supplementation treats diabetes.

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