Tier 1 — highest

Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis

J Iwamoto, T Takeda, S Ichimura
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2000 5(6):546-51

Bibliography

PubMed
PMID 11180916
DOI
10.1007/s007760070003
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample92 postmenopausal women with osteoporosis randomized to four groups
InterventionAlfacalcidol 0.75 μg/day, MK-4 45 mg/day, both, or calcium lactate
Duration2 years
EndpointsLumbar spine bone mineral density

What the study showed, in plain terms

This publication examines lumbar spine bone mineral density. Study population or evidence base: 92 postmenopausal women with osteoporosis randomized to four groups. Intervention or exposure: Alfacalcidol 0.75 μg/day, MK-4 45 mg/day, both, or calcium lactate.

Key findings

Combined alfacalcidol and high-dose MK-4 improved lumbar bone density more than the calcium comparison and either active nutrient treatment alone.

What this study can and cannot tell us

The vitamin D intervention was an active analogue, not ordinary cholecalciferol. The MK-4 dose was pharmacological and cannot be treated as evidence for a low-dose MK-7/D3 capsule.

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