Tier 1 — highest

Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review

Ming Zhou, Shiliang Han, Wenpeng Zhang, Dan Wu
Journal of bone and mineral metabolism 2022 40(5):763-772

Bibliography

PubMed
PMID 35711002
DOI
10.1007/s00774-022-01342-6
Funding
Support is recorded from the Key Research and Development Project of Shandong Province. See the original publication for grant and material-support details.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignSystematic review and meta-analysis
ModelHuman evidence synthesis
Sample9 randomized trials involving 6,853 participants
InterventionDifferent K2 regimens in postmenopausal osteoporosis
DurationLonger-term follow-up; varied by trial
EndpointsBone mineral density; Osteocalcin; Adverse reactions

What the study showed, in plain terms

This publication examines bone mineral density, osteocalcin, adverse reactions. Study population or evidence base: 9 randomized trials involving 6,853 participants. Intervention or exposure: Different K2 regimens in postmenopausal osteoporosis.

Key findings

Pooling favored K2 for lumbar and forearm bone-density measures and osteocalcin outcomes. Adverse reactions were more frequent overall, although the review reported no serious K2-related events.

What this study can and cannot tell us

Formulations, co-treatments and trial methods differed. This review overlaps other K2 meta-analyses and is not an independent set of participants.

Related papers in the corpus

Tier 1
Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women
M H J Knapen et al. · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013
Tier 1
The effect of vitamin MK-7 on bone mineral density and microarchitecture in postmenopausal women with osteopenia, a 3-year randomized, placebo-controlled clinical trial
S H Rønn et al. · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021
Tier 1
Vitamin K2 (menaquinone-7) prevents age-related deterioration of trabecular bone microarchitecture at the tibia in postmenopausal women
Sofie Hertz Rønn et al. · European journal of endocrinology · 2016
Tier 1
Vitamin K2 supplementation does not influence bone loss in early menopausal women: a randomised double-blind placebo-controlled trial
N Emaus et al. · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2010
Tier 1
Effect of Low-Dose Vitamin K2 Supplementation on Bone Mineral Density in Middle-Aged and Elderly Chinese: A Randomized Controlled Study
Yingfeng Zhang et al. · Calcified tissue international · 2020
Tier 1
Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women
M H J Knapen et al. · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2007

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Biohack Blueprint Research