Tier 1 — highest

Vitamin K2 (menaquinone-7) prevents age-related deterioration of trabecular bone microarchitecture at the tibia in postmenopausal women

Sofie Hertz Rønn, Torben Harsløf, Steen Bønløkke Pedersen, Bente Lomholt Langdahl
European journal of endocrinology 2016 175(6):541-549

Bibliography

PubMed
PMID 27625301
DOI
10.1530/EJE-16-0498
Trial registry
View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample148 postmenopausal women with osteopenia
InterventionMK-7 375 μg/day or placebo, alongside calcium and vitamin D
Duration12 months
EndpointsTibial and radial microarchitecture; Bone mineral density; Undercarboxylated osteocalcin

What the study showed, in plain terms

This publication examines tibial and radial microarchitecture, bone mineral density, undercarboxylated osteocalcin. Study population or evidence base: 148 postmenopausal women with osteopenia. Intervention or exposure: MK-7 375 μg/day or placebo, alongside calcium and vitamin D.

Key findings

MK-7 improved osteocalcin carboxylation and preserved selected tibial trabecular measures. Bone density and radial microarchitecture did not significantly differ.

What this study can and cannot tell us

The one-year findings should be considered with the neutral three-year bone-density and microarchitecture report from the same trial. Imaging biomarkers are not fracture outcomes.

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