Tier 1 — highest

Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women

M H J Knapen, L J Schurgers, C Vermeer
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2007 18(7):963-72

Bibliography

PubMed
PMID 17287908
PubMed Central
PMC1915640
DOI
10.1007/s00198-007-0337-9
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample325 postmenopausal women
InterventionMK-4 45 mg/day or placebo
Duration3 years
EndpointsHip bone mineral content; Femoral-neck geometry; Estimated bone strength; DXA bone density

What the study showed, in plain terms

This publication examines hip bone mineral content, femoral-neck geometry, estimated bone strength, dxa bone density. Study population or evidence base: 325 postmenopausal women. Intervention or exposure: MK-4 45 mg/day or placebo.

Key findings

High-dose MK-4 improved femoral-neck width and mineral-content measures and helped preserve estimated hip strength, while conventional DXA bone density was not improved.

What this study can and cannot tell us

The pharmacological MK-4 dose differs greatly from nutritional-dose MK-7. Calculated strength indices do not demonstrate fewer fractures.

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