Tier 1 — highest

Vitamin K2 supplementation does not influence bone loss in early menopausal women: a randomised double-blind placebo-controlled trial

N Emaus, C G Gjesdal, B Almås, M Christensen, A S Grimsgaard, G K R Berntsen, L Salomonsen, V Fønnebø
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2010 21(10):1731-40

Bibliography

PubMed
PMID 19937427
DOI
10.1007/s00198-009-1126-4
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample334 healthy Norwegian women in early menopause
InterventionMK-7 360 μg/day as natto capsules or placebo
Duration12 months
EndpointsBone loss at hip, spine and other sites; Osteocalcin carboxylation

What the study showed, in plain terms

This publication examines bone loss at hip, spine and other sites, osteocalcin carboxylation. Study population or evidence base: 334 healthy Norwegian women in early menopause. Intervention or exposure: MK-7 360 μg/day as natto capsules or placebo.

Key findings

Supplementation improved osteocalcin carboxylation but did not significantly change bone-loss rates at any measured site.

What this study can and cannot tell us

One-year results in early menopausal women cannot answer longer-term fracture prevention. Improved vitamin K biomarkers did not translate into measurable bone-density benefit here.

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