Tier 1 — highest

Effect of Low-Dose Vitamin K2 Supplementation on Bone Mineral Density in Middle-Aged and Elderly Chinese: A Randomized Controlled Study

Yingfeng Zhang, Zhipeng Liu, Lili Duan, Yeyu Ji, Sen Yang, Yuan Zhang, Hongyin Li, Yu Wang, Peng Wang, Jiepeng Chen, Ying Li
Calcified tissue international 2020 106(5):476-485

Bibliography

PubMed
PMID 32060566
DOI
10.1007/s00223-020-00669-4
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample311 community-dwelling adults aged 50–75
InterventionVitamin K2 50 or 90 μg/day; a further 90 μg group also received calcium and D3; placebo control
Duration1 year
EndpointsBone mineral density; Osteocalcin carboxylation

What the study showed, in plain terms

This publication examines bone mineral density, osteocalcin carboxylation. Study population or evidence base: 311 community-dwelling adults aged 50–75. Intervention or exposure: Vitamin K2 50 or 90 μg/day; a further 90 μg group also received calcium and D3; placebo control.

Key findings

The 90 μg regimens reduced femoral-neck bone loss in postmenopausal women, but not men. Adding calcium and D3 did not provide additional benefit in this study.

What this study can and cannot tell us

Benefits were population- and site-specific. The results do not demonstrate universal effects in men or prove that combined supplementation is superior.

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