Tier 1 — highest

Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women

Noriko Koitaya, Mariko Sekiguchi, Yuko Tousen, Yoriko Nishide, Akemi Morita, Jun Yamauchi, Yuko Gando, Motohiko Miyachi, Mami Aoki, Miho Komatsu, Fumiko Watanabe, Koji Morishita, Yoshiko Ishimi
Journal of bone and mineral metabolism 2014 32(2):142-50

Bibliography

PubMed
PMID 23702931
DOI
10.1007/s00774-013-0472-7
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignRandomized controlled clinical trial
ModelHuman participants
Sample48 postmenopausal Japanese women
InterventionMK-4 1.5 mg/day or placebo
Duration12 months
EndpointsUndercarboxylated osteocalcin; Pentosidine; Forearm bone density

What the study showed, in plain terms

This publication examines undercarboxylated osteocalcin, pentosidine, forearm bone density. Study population or evidence base: 48 postmenopausal Japanese women. Intervention or exposure: MK-4 1.5 mg/day or placebo.

Key findings

MK-4 reduced undercarboxylated osteocalcin and pentosidine. Forearm bone density declined in controls but was maintained in the intervention group over the reported interval.

What this study can and cannot tell us

A small trial of MK-4 with biomarker and forearm-density endpoints. Its dose and formulation should be distinguished from MK-7 supplements.

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